Multicenter Cross-sectional Study of Patients with Rheumatoid Arthritis in Greece: Results from a cohort of 2.491 patients
Identifieur interne : 001284 ( Main/Exploration ); précédent : 001283; suivant : 001285Multicenter Cross-sectional Study of Patients with Rheumatoid Arthritis in Greece: Results from a cohort of 2.491 patients
Auteurs : Konstantinos Thomas [Grèce] ; Argiro Lazarini [Grèce] ; Evripidis Kaltsonoudis [Grèce] ; Alexandros Drosos [Grèce] ; Ioannis Papalopoulos [Grèce] ; Prodromos Sidiropoulos [Grèce] ; Pelagia Katsimbri [Grèce] ; Dimitrios Boumpas [Grèce] ; Panagiota Tsatsani [Grèce] ; Sousana Gazi [Grèce] ; Kalliopi Fragkiadaki [Grèce] ; Maria Tektonidou [Grèce] ; Petros P. Sfikakis [Grèce] ; Lina Pantazi [Grèce] ; Kyriaki A. Boki [Grèce] ; Eleftheria P. Grika [Grèce] ; Panagiotis G. Vlachoyiannopoulos [Grèce] ; Konstantina Karagianni [Grèce] ; Lazaros I. Sakkas [Grèce] ; Theodoros Dimitroulas [Grèce] ; Alexandros Garyfallos [Grèce] ; Dimitrios Kassimos [Grèce] ; Gerasimos Evangelatos [Grèce] ; Alexios Iliopoulos [Grèce] ; Maria Areti [Grèce] ; Constantinos Georganas [Grèce] ; Konstantinos Melissaropoulos [Grèce] ; Panagiotis Georgiou [Grèce] ; Periklis Vounotrypidis [Grèce] ; Konstantinos Ntelis [Grèce] ; Clio P. Mavragani [Grèce] ; Ilias Bournazos [Grèce] ; Gikas Katsifis [Grèce] ; Christos Mavrommatis [Grèce] ; George D. Kitas [Grèce] ; Dimitrios Vassilopoulos [Grèce]Source :
- Mediterranean Journal of Rheumatology [ 2529-198X ] ; 2018.
Abstract
To evaluate the current disease characteristics, treatment and comorbidities of rheumatoid arthritis (RA) in Greece.
Multicenter, cross-sectional study with a 9-month recruitment period between 2015 and 2016. Demographics, disease characteristics, treatment and comorbidities were collected via a web-based platform.
2.491 RA patients were recruited: 96% from tertiary referral centers, 79% were females with a mean age of 63.1 years and disease duration of 9.9 years. Fifty-two percent were rheumatoid factor and/or anti-CCP positive, while 41% had erosive disease. Regarding treatment, 82% were on conventional synthetic disease modifying anti-rheumatic drugs (csDMARDs), 42% on biologic DMARDs (TNFi: 22%, non-TNFi: 20%) and 40% on corticosteroids (mean daily dose: 5.2 mg). Despite therapy, 36% of patients had moderate and 12% high disease activity. The most frequent comorbidities were hypertension (42%), hyperlipidemia (33%), osteoporosis (29%), diabetes mellitus (15%) and depression (12%). Latent tuberculosis infection (positive tuberculin skin test or interferon gamma release assay) was diagnosed in 13 and 15.3% of patients, respectively. Regarding chronic viral infections, 6.2% had history of herpes zoster while 2% and 0.7% had chronic hepatitis B and C virus infection, respectively. A history of serious infection was documented in 9.6%. Only 36% and 52% of the participants had ever been vaccinated against pneumococcus and influenza virus, respectively.
This is one of the largest epidemiologic studies providing valuable data regarding the current RA characteristics in Greece. Half of patients were seropositive but despite therapy, half displayed residual disease activity, while preventive vaccination was limited.
Url:
DOI: 10.31138/mjr.29.1.27
PubMed: 32185294
PubMed Central: 7045959
Affiliations:
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Grika</name><affiliation wicri:level="3"><nlm:aff id="AFF1">Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Vlachoyiannopoulos, Panagiotis G" sort="Vlachoyiannopoulos, Panagiotis G" uniqKey="Vlachoyiannopoulos P" first="Panagiotis G." last="Vlachoyiannopoulos">Panagiotis G. Vlachoyiannopoulos</name><affiliation wicri:level="3"><nlm:aff id="AFF1">Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Karagianni, Konstantina" sort="Karagianni, Konstantina" uniqKey="Karagianni K" first="Konstantina" last="Karagianni">Konstantina Karagianni</name><affiliation wicri:level="1"><nlm:aff id="AFF6">Department of Rheumatology, University of Thessaly, Larissa, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Rheumatology, University of Thessaly, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Sakkas, Lazaros I" sort="Sakkas, Lazaros I" uniqKey="Sakkas L" first="Lazaros I." last="Sakkas">Lazaros I. Sakkas</name><affiliation wicri:level="1"><nlm:aff id="AFF6">Department of Rheumatology, University of Thessaly, Larissa, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Rheumatology, University of Thessaly, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Dimitroulas, Theodoros" sort="Dimitroulas, Theodoros" uniqKey="Dimitroulas T" first="Theodoros" last="Dimitroulas">Theodoros Dimitroulas</name><affiliation wicri:level="1"><nlm:aff id="AFF7">4<sup>th</sup> Department of Medicine, Aristotle University, Thessaloniki, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Department of Medicine, Aristotle University, Thessaloniki</wicri:regionArea><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Garyfallos, Alexandros" sort="Garyfallos, Alexandros" uniqKey="Garyfallos A" first="Alexandros" last="Garyfallos">Alexandros Garyfallos</name><affiliation wicri:level="1"><nlm:aff id="AFF7">4<sup>th</sup> Department of Medicine, Aristotle University, Thessaloniki, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Department of Medicine, Aristotle University, Thessaloniki</wicri:regionArea><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Kassimos, Dimitrios" sort="Kassimos, Dimitrios" uniqKey="Kassimos D" first="Dimitrios" last="Kassimos">Dimitrios Kassimos</name><affiliation wicri:level="3"><nlm:aff id="AFF8">401 General Military Hospital, Athens, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>401 General Military Hospital, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Evangelatos, Gerasimos" sort="Evangelatos, Gerasimos" uniqKey="Evangelatos G" first="Gerasimos" last="Evangelatos">Gerasimos Evangelatos</name><affiliation wicri:level="3"><nlm:aff id="AFF9">Rheumatology Unit, NIMTS Hospital, Athens, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Rheumatology Unit, NIMTS Hospital, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Iliopoulos, Alexios" sort="Iliopoulos, Alexios" uniqKey="Iliopoulos A" first="Alexios" last="Iliopoulos">Alexios Iliopoulos</name><affiliation wicri:level="3"><nlm:aff id="AFF9">Rheumatology Unit, NIMTS Hospital, Athens, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Rheumatology Unit, NIMTS Hospital, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Areti, Maria" sort="Areti, Maria" uniqKey="Areti M" first="Maria" last="Areti">Maria Areti</name><affiliation wicri:level="1"><nlm:aff id="AFF10">Private Practice, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Private Practice</wicri:regionArea></affiliation></author><author><name sortKey="Georganas, Constantinos" sort="Georganas, Constantinos" uniqKey="Georganas C" first="Constantinos" last="Georganas">Constantinos Georganas</name><affiliation wicri:level="1"><nlm:aff id="AFF10">Private Practice, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Private Practice</wicri:regionArea></affiliation></author><author><name sortKey="Melissaropoulos, Konstantinos" sort="Melissaropoulos, Konstantinos" uniqKey="Melissaropoulos K" first="Konstantinos" last="Melissaropoulos">Konstantinos Melissaropoulos</name><affiliation wicri:level="1"><nlm:aff id="AFF11">Rheumatology Unit, Agios Andreas Hospital, Patras, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Rheumatology Unit, Agios Andreas Hospital, Patras</wicri:regionArea><wicri:noRegion>Patras</wicri:noRegion></affiliation></author><author><name sortKey="Georgiou, Panagiotis" sort="Georgiou, Panagiotis" uniqKey="Georgiou P" first="Panagiotis" last="Georgiou">Panagiotis Georgiou</name><affiliation wicri:level="1"><nlm:aff id="AFF11">Rheumatology Unit, Agios Andreas Hospital, Patras, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Rheumatology Unit, Agios Andreas Hospital, Patras</wicri:regionArea><wicri:noRegion>Patras</wicri:noRegion></affiliation></author><author><name sortKey="Vounotrypidis, Periklis" sort="Vounotrypidis, Periklis" uniqKey="Vounotrypidis P" first="Periklis" last="Vounotrypidis">Periklis Vounotrypidis</name><affiliation wicri:level="1"><nlm:aff id="AFF10">Private Practice, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Private Practice</wicri:regionArea></affiliation></author><author><name sortKey="Ntelis, Konstantinos" sort="Ntelis, Konstantinos" uniqKey="Ntelis K" first="Konstantinos" last="Ntelis">Konstantinos Ntelis</name><affiliation wicri:level="1"><nlm:aff id="AFF10">Private Practice, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Private Practice</wicri:regionArea></affiliation></author><author><name sortKey="Mavragani, Clio P" sort="Mavragani, Clio P" uniqKey="Mavragani C" first="Clio P." last="Mavragani">Clio P. Mavragani</name><affiliation wicri:level="3"><nlm:aff id="AFF1">Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Bournazos, Ilias" sort="Bournazos, Ilias" uniqKey="Bournazos I" first="Ilias" last="Bournazos">Ilias Bournazos</name><affiliation wicri:level="1"><nlm:aff id="AFF10">Private Practice, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Private Practice</wicri:regionArea></affiliation></author><author><name sortKey="Katsifis, Gikas" sort="Katsifis, Gikas" uniqKey="Katsifis G" first="Gikas" last="Katsifis">Gikas Katsifis</name><affiliation wicri:level="3"><nlm:aff id="AFF12">Rheumatology Unit, Navy Hospital, Athens, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Rheumatology Unit, Navy Hospital, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Mavrommatis, Christos" sort="Mavrommatis, Christos" uniqKey="Mavrommatis C" first="Christos" last="Mavrommatis">Christos Mavrommatis</name><affiliation wicri:level="1"><nlm:aff id="AFF10">Private Practice, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Private Practice</wicri:regionArea></affiliation></author><author><name sortKey="Kitas, George D" sort="Kitas, George D" uniqKey="Kitas G" first="George D." last="Kitas">George D. Kitas</name><affiliation wicri:level="3"><nlm:aff id="AFF1">Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="AFF13">Hygeia Hospital, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Hygeia Hospital, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Vassilopoulos, Dimitrios" sort="Vassilopoulos, Dimitrios" uniqKey="Vassilopoulos D" first="Dimitrios" last="Vassilopoulos">Dimitrios Vassilopoulos</name><affiliation wicri:level="3"><nlm:aff id="AFF1">Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32185294</idno><idno type="pmc">7045959</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045959</idno><idno type="RBID">PMC:7045959</idno><idno type="doi">10.31138/mjr.29.1.27</idno><date when="2018">2018</date><idno type="wicri:Area/Pmc/Corpus">000C20</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000C20</idno><idno type="wicri:Area/Pmc/Curation">000C20</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000C20</idno><idno type="wicri:Area/Pmc/Checkpoint">000C52</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000C52</idno><idno type="wicri:Area/Ncbi/Merge">002A11</idno><idno type="wicri:Area/Ncbi/Curation">002A11</idno><idno type="wicri:Area/Ncbi/Checkpoint">002A11</idno><idno type="wicri:Area/Main/Merge">001283</idno><idno type="wicri:Area/Main/Curation">001284</idno><idno type="wicri:Area/Main/Exploration">001284</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Multicenter Cross-sectional Study of Patients with Rheumatoid Arthritis in Greece: Results from a cohort of 2.491 patients</title><author><name sortKey="Thomas, Konstantinos" sort="Thomas, Konstantinos" uniqKey="Thomas K" first="Konstantinos" last="Thomas">Konstantinos Thomas</name><affiliation wicri:level="3"><nlm:aff id="AFF1">Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Lazarini, Argiro" sort="Lazarini, Argiro" uniqKey="Lazarini A" first="Argiro" last="Lazarini">Argiro Lazarini</name><affiliation wicri:level="3"><nlm:aff id="AFF1">Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Kaltsonoudis, Evripidis" sort="Kaltsonoudis, Evripidis" uniqKey="Kaltsonoudis E" first="Evripidis" last="Kaltsonoudis">Evripidis Kaltsonoudis</name><affiliation wicri:level="1"><nlm:aff id="AFF2">Rheumatology Clinic, University of Ioannina, Ioannina, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Rheumatology Clinic, University of Ioannina, Ioannina</wicri:regionArea><wicri:noRegion>Ioannina</wicri:noRegion></affiliation></author><author><name sortKey="Drosos, Alexandros" sort="Drosos, Alexandros" uniqKey="Drosos A" first="Alexandros" last="Drosos">Alexandros Drosos</name><affiliation wicri:level="1"><nlm:aff id="AFF2">Rheumatology Clinic, University of Ioannina, Ioannina, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Rheumatology Clinic, University of Ioannina, Ioannina</wicri:regionArea><wicri:noRegion>Ioannina</wicri:noRegion></affiliation></author><author><name sortKey="Papalopoulos, Ioannis" sort="Papalopoulos, Ioannis" uniqKey="Papalopoulos I" first="Ioannis" last="Papalopoulos">Ioannis Papalopoulos</name><affiliation wicri:level="1"><nlm:aff id="AFF3">Clinical Immunology and Allergy Department, University of Crete, Heraklion, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Clinical Immunology and Allergy Department, University of Crete, Heraklion</wicri:regionArea><wicri:noRegion>Heraklion</wicri:noRegion></affiliation></author><author><name sortKey="Sidiropoulos, Prodromos" sort="Sidiropoulos, Prodromos" uniqKey="Sidiropoulos P" first="Prodromos" last="Sidiropoulos">Prodromos Sidiropoulos</name><affiliation wicri:level="1"><nlm:aff id="AFF3">Clinical Immunology and Allergy Department, University of Crete, Heraklion, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Clinical Immunology and Allergy Department, University of Crete, Heraklion</wicri:regionArea><wicri:noRegion>Heraklion</wicri:noRegion></affiliation></author><author><name sortKey="Katsimbri, Pelagia" sort="Katsimbri, Pelagia" uniqKey="Katsimbri P" first="Pelagia" last="Katsimbri">Pelagia Katsimbri</name><affiliation wicri:level="3"><nlm:aff id="AFF1">Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Boumpas, Dimitrios" sort="Boumpas, Dimitrios" uniqKey="Boumpas D" first="Dimitrios" last="Boumpas">Dimitrios Boumpas</name><affiliation wicri:level="3"><nlm:aff id="AFF1">Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Tsatsani, Panagiota" sort="Tsatsani, Panagiota" uniqKey="Tsatsani P" first="Panagiota" last="Tsatsani">Panagiota Tsatsani</name><affiliation wicri:level="3"><nlm:aff id="AFF4">Rheumatology Unit, KAT Hospital, Athens, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Rheumatology Unit, KAT Hospital, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Gazi, Sousana" sort="Gazi, Sousana" uniqKey="Gazi S" first="Sousana" last="Gazi">Sousana Gazi</name><affiliation wicri:level="3"><nlm:aff id="AFF4">Rheumatology Unit, KAT Hospital, Athens, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Rheumatology Unit, KAT Hospital, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Fragkiadaki, Kalliopi" sort="Fragkiadaki, Kalliopi" uniqKey="Fragkiadaki K" first="Kalliopi" last="Fragkiadaki">Kalliopi Fragkiadaki</name><affiliation wicri:level="3"><nlm:aff id="AFF1">Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Tektonidou, Maria" sort="Tektonidou, Maria" uniqKey="Tektonidou M" first="Maria" last="Tektonidou">Maria Tektonidou</name><affiliation wicri:level="3"><nlm:aff id="AFF1">Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Sfikakis, Petros P" sort="Sfikakis, Petros P" uniqKey="Sfikakis P" first="Petros P." last="Sfikakis">Petros P. Sfikakis</name><affiliation wicri:level="3"><nlm:aff id="AFF1">Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Pantazi, Lina" sort="Pantazi, Lina" uniqKey="Pantazi L" first="Lina" last="Pantazi">Lina Pantazi</name><affiliation wicri:level="3"><nlm:aff id="AFF5">Rheumatology Unit, Sismanoglio Hospital, Athens, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Rheumatology Unit, Sismanoglio Hospital, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Boki, Kyriaki A" sort="Boki, Kyriaki A" uniqKey="Boki K" first="Kyriaki A." last="Boki">Kyriaki A. Boki</name><affiliation wicri:level="3"><nlm:aff id="AFF5">Rheumatology Unit, Sismanoglio Hospital, Athens, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Rheumatology Unit, Sismanoglio Hospital, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Grika, Eleftheria P" sort="Grika, Eleftheria P" uniqKey="Grika E" first="Eleftheria P." last="Grika">Eleftheria P. Grika</name><affiliation wicri:level="3"><nlm:aff id="AFF1">Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Vlachoyiannopoulos, Panagiotis G" sort="Vlachoyiannopoulos, Panagiotis G" uniqKey="Vlachoyiannopoulos P" first="Panagiotis G." last="Vlachoyiannopoulos">Panagiotis G. Vlachoyiannopoulos</name><affiliation wicri:level="3"><nlm:aff id="AFF1">Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Karagianni, Konstantina" sort="Karagianni, Konstantina" uniqKey="Karagianni K" first="Konstantina" last="Karagianni">Konstantina Karagianni</name><affiliation wicri:level="1"><nlm:aff id="AFF6">Department of Rheumatology, University of Thessaly, Larissa, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Rheumatology, University of Thessaly, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Sakkas, Lazaros I" sort="Sakkas, Lazaros I" uniqKey="Sakkas L" first="Lazaros I." last="Sakkas">Lazaros I. Sakkas</name><affiliation wicri:level="1"><nlm:aff id="AFF6">Department of Rheumatology, University of Thessaly, Larissa, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Rheumatology, University of Thessaly, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Dimitroulas, Theodoros" sort="Dimitroulas, Theodoros" uniqKey="Dimitroulas T" first="Theodoros" last="Dimitroulas">Theodoros Dimitroulas</name><affiliation wicri:level="1"><nlm:aff id="AFF7">4<sup>th</sup> Department of Medicine, Aristotle University, Thessaloniki, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Department of Medicine, Aristotle University, Thessaloniki</wicri:regionArea><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Garyfallos, Alexandros" sort="Garyfallos, Alexandros" uniqKey="Garyfallos A" first="Alexandros" last="Garyfallos">Alexandros Garyfallos</name><affiliation wicri:level="1"><nlm:aff id="AFF7">4<sup>th</sup> Department of Medicine, Aristotle University, Thessaloniki, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Department of Medicine, Aristotle University, Thessaloniki</wicri:regionArea><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Kassimos, Dimitrios" sort="Kassimos, Dimitrios" uniqKey="Kassimos D" first="Dimitrios" last="Kassimos">Dimitrios Kassimos</name><affiliation wicri:level="3"><nlm:aff id="AFF8">401 General Military Hospital, Athens, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>401 General Military Hospital, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Evangelatos, Gerasimos" sort="Evangelatos, Gerasimos" uniqKey="Evangelatos G" first="Gerasimos" last="Evangelatos">Gerasimos Evangelatos</name><affiliation wicri:level="3"><nlm:aff id="AFF9">Rheumatology Unit, NIMTS Hospital, Athens, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Rheumatology Unit, NIMTS Hospital, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Iliopoulos, Alexios" sort="Iliopoulos, Alexios" uniqKey="Iliopoulos A" first="Alexios" last="Iliopoulos">Alexios Iliopoulos</name><affiliation wicri:level="3"><nlm:aff id="AFF9">Rheumatology Unit, NIMTS Hospital, Athens, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Rheumatology Unit, NIMTS Hospital, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Areti, Maria" sort="Areti, Maria" uniqKey="Areti M" first="Maria" last="Areti">Maria Areti</name><affiliation wicri:level="1"><nlm:aff id="AFF10">Private Practice, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Private Practice</wicri:regionArea></affiliation></author><author><name sortKey="Georganas, Constantinos" sort="Georganas, Constantinos" uniqKey="Georganas C" first="Constantinos" last="Georganas">Constantinos Georganas</name><affiliation wicri:level="1"><nlm:aff id="AFF10">Private Practice, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Private Practice</wicri:regionArea></affiliation></author><author><name sortKey="Melissaropoulos, Konstantinos" sort="Melissaropoulos, Konstantinos" uniqKey="Melissaropoulos K" first="Konstantinos" last="Melissaropoulos">Konstantinos Melissaropoulos</name><affiliation wicri:level="1"><nlm:aff id="AFF11">Rheumatology Unit, Agios Andreas Hospital, Patras, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Rheumatology Unit, Agios Andreas Hospital, Patras</wicri:regionArea><wicri:noRegion>Patras</wicri:noRegion></affiliation></author><author><name sortKey="Georgiou, Panagiotis" sort="Georgiou, Panagiotis" uniqKey="Georgiou P" first="Panagiotis" last="Georgiou">Panagiotis Georgiou</name><affiliation wicri:level="1"><nlm:aff id="AFF11">Rheumatology Unit, Agios Andreas Hospital, Patras, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Rheumatology Unit, Agios Andreas Hospital, Patras</wicri:regionArea><wicri:noRegion>Patras</wicri:noRegion></affiliation></author><author><name sortKey="Vounotrypidis, Periklis" sort="Vounotrypidis, Periklis" uniqKey="Vounotrypidis P" first="Periklis" last="Vounotrypidis">Periklis Vounotrypidis</name><affiliation wicri:level="1"><nlm:aff id="AFF10">Private Practice, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Private Practice</wicri:regionArea></affiliation></author><author><name sortKey="Ntelis, Konstantinos" sort="Ntelis, Konstantinos" uniqKey="Ntelis K" first="Konstantinos" last="Ntelis">Konstantinos Ntelis</name><affiliation wicri:level="1"><nlm:aff id="AFF10">Private Practice, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Private Practice</wicri:regionArea></affiliation></author><author><name sortKey="Mavragani, Clio P" sort="Mavragani, Clio P" uniqKey="Mavragani C" first="Clio P." last="Mavragani">Clio P. Mavragani</name><affiliation wicri:level="3"><nlm:aff id="AFF1">Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Bournazos, Ilias" sort="Bournazos, Ilias" uniqKey="Bournazos I" first="Ilias" last="Bournazos">Ilias Bournazos</name><affiliation wicri:level="1"><nlm:aff id="AFF10">Private Practice, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Private Practice</wicri:regionArea></affiliation></author><author><name sortKey="Katsifis, Gikas" sort="Katsifis, Gikas" uniqKey="Katsifis G" first="Gikas" last="Katsifis">Gikas Katsifis</name><affiliation wicri:level="3"><nlm:aff id="AFF12">Rheumatology Unit, Navy Hospital, Athens, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Rheumatology Unit, Navy Hospital, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Mavrommatis, Christos" sort="Mavrommatis, Christos" uniqKey="Mavrommatis C" first="Christos" last="Mavrommatis">Christos Mavrommatis</name><affiliation wicri:level="1"><nlm:aff id="AFF10">Private Practice, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Private Practice</wicri:regionArea></affiliation></author><author><name sortKey="Kitas, George D" sort="Kitas, George D" uniqKey="Kitas G" first="George D." last="Kitas">George D. Kitas</name><affiliation wicri:level="3"><nlm:aff id="AFF1">Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="AFF13">Hygeia Hospital, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Hygeia Hospital, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Vassilopoulos, Dimitrios" sort="Vassilopoulos, Dimitrios" uniqKey="Vassilopoulos D" first="Dimitrios" last="Vassilopoulos">Dimitrios Vassilopoulos</name><affiliation wicri:level="3"><nlm:aff id="AFF1">Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author></analytic><series><title level="j">Mediterranean Journal of Rheumatology</title><idno type="eISSN">2529-198X</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Aim of the study:</title><p>To evaluate the current disease characteristics, treatment and comorbidities of rheumatoid arthritis (RA) in Greece.</p></sec><sec><title>Methods:</title><p>Multicenter, cross-sectional study with a 9-month recruitment period between 2015 and 2016. Demographics, disease characteristics, treatment and comorbidities were collected via a web-based platform.</p></sec><sec><title>Results:</title><p>2.491 RA patients were recruited: 96% from tertiary referral centers, 79% were females with a mean age of 63.1 years and disease duration of 9.9 years. Fifty-two percent were rheumatoid factor and/or anti-CCP positive, while 41% had erosive disease. Regarding treatment, 82% were on conventional synthetic disease modifying anti-rheumatic drugs (csDMARDs), 42% on biologic DMARDs (TNFi: 22%, non-TNFi: 20%) and 40% on corticosteroids (mean daily dose: 5.2 mg). Despite therapy, 36% of patients had moderate and 12% high disease activity. The most frequent comorbidities were hypertension (42%), hyperlipidemia (33%), osteoporosis (29%), diabetes mellitus (15%) and depression (12%). Latent tuberculosis infection (positive tuberculin skin test or interferon gamma release assay) was diagnosed in 13 and 15.3% of patients, respectively. Regarding chronic viral infections, 6.2% had history of herpes zoster while 2% and 0.7% had chronic hepatitis B and C virus infection, respectively. A history of serious infection was documented in 9.6%. Only 36% and 52% of the participants had ever been vaccinated against pneumococcus and influenza virus, respectively.</p></sec><sec><title>Conclusion:</title><p>This is one of the largest epidemiologic studies providing valuable data regarding the current RA characteristics in Greece. Half of patients were seropositive but despite therapy, half displayed residual disease activity, while preventive vaccination was limited.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Smolen, Js" uniqKey="Smolen J">JS Smolen</name></author><author><name sortKey="Aletaha, D" uniqKey="Aletaha D">D Aletaha</name></author><author><name sortKey="Mcinnes, Ib" uniqKey="Mcinnes I">IB. McInnes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alamanos, Y" uniqKey="Alamanos Y">Y Alamanos</name></author><author><name sortKey="Voulgari, Pv" uniqKey="Voulgari P">PV Voulgari</name></author><author><name sortKey="Drosos, Aa" uniqKey="Drosos A">AA. 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Vassilopoulos</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Grèce</li></country><region><li>Attique (région)</li></region><settlement><li>Athènes</li></settlement></list><tree><country name="Grèce"><region name="Attique (région)"><name sortKey="Thomas, Konstantinos" sort="Thomas, Konstantinos" uniqKey="Thomas K" first="Konstantinos" last="Thomas">Konstantinos Thomas</name></region><name sortKey="Areti, Maria" sort="Areti, Maria" uniqKey="Areti M" first="Maria" last="Areti">Maria Areti</name><name sortKey="Boki, Kyriaki A" sort="Boki, Kyriaki A" uniqKey="Boki K" first="Kyriaki A." last="Boki">Kyriaki A. Boki</name><name sortKey="Boumpas, Dimitrios" sort="Boumpas, Dimitrios" uniqKey="Boumpas D" first="Dimitrios" last="Boumpas">Dimitrios Boumpas</name><name sortKey="Bournazos, Ilias" sort="Bournazos, Ilias" uniqKey="Bournazos I" first="Ilias" last="Bournazos">Ilias Bournazos</name><name sortKey="Dimitroulas, Theodoros" sort="Dimitroulas, Theodoros" uniqKey="Dimitroulas T" first="Theodoros" last="Dimitroulas">Theodoros Dimitroulas</name><name sortKey="Drosos, Alexandros" sort="Drosos, Alexandros" uniqKey="Drosos A" first="Alexandros" last="Drosos">Alexandros Drosos</name><name sortKey="Evangelatos, Gerasimos" sort="Evangelatos, Gerasimos" uniqKey="Evangelatos G" first="Gerasimos" last="Evangelatos">Gerasimos Evangelatos</name><name sortKey="Fragkiadaki, Kalliopi" sort="Fragkiadaki, Kalliopi" uniqKey="Fragkiadaki K" first="Kalliopi" last="Fragkiadaki">Kalliopi Fragkiadaki</name><name sortKey="Garyfallos, Alexandros" sort="Garyfallos, Alexandros" uniqKey="Garyfallos A" first="Alexandros" last="Garyfallos">Alexandros Garyfallos</name><name sortKey="Gazi, Sousana" sort="Gazi, Sousana" uniqKey="Gazi S" first="Sousana" last="Gazi">Sousana Gazi</name><name sortKey="Georganas, Constantinos" sort="Georganas, Constantinos" uniqKey="Georganas C" first="Constantinos" last="Georganas">Constantinos Georganas</name><name sortKey="Georgiou, Panagiotis" sort="Georgiou, Panagiotis" uniqKey="Georgiou P" first="Panagiotis" last="Georgiou">Panagiotis Georgiou</name><name sortKey="Grika, Eleftheria P" sort="Grika, Eleftheria P" uniqKey="Grika E" first="Eleftheria P." last="Grika">Eleftheria P. Grika</name><name sortKey="Iliopoulos, Alexios" sort="Iliopoulos, Alexios" uniqKey="Iliopoulos A" first="Alexios" last="Iliopoulos">Alexios Iliopoulos</name><name sortKey="Kaltsonoudis, Evripidis" sort="Kaltsonoudis, Evripidis" uniqKey="Kaltsonoudis E" first="Evripidis" last="Kaltsonoudis">Evripidis Kaltsonoudis</name><name sortKey="Karagianni, Konstantina" sort="Karagianni, Konstantina" uniqKey="Karagianni K" first="Konstantina" last="Karagianni">Konstantina Karagianni</name><name sortKey="Kassimos, Dimitrios" sort="Kassimos, Dimitrios" uniqKey="Kassimos D" first="Dimitrios" last="Kassimos">Dimitrios Kassimos</name><name sortKey="Katsifis, Gikas" sort="Katsifis, Gikas" uniqKey="Katsifis G" first="Gikas" last="Katsifis">Gikas Katsifis</name><name sortKey="Katsimbri, Pelagia" sort="Katsimbri, Pelagia" uniqKey="Katsimbri P" first="Pelagia" last="Katsimbri">Pelagia Katsimbri</name><name sortKey="Kitas, George D" sort="Kitas, George D" uniqKey="Kitas G" first="George D." last="Kitas">George D. Kitas</name><name sortKey="Kitas, George D" sort="Kitas, George D" uniqKey="Kitas G" first="George D." last="Kitas">George D. Kitas</name><name sortKey="Lazarini, Argiro" sort="Lazarini, Argiro" uniqKey="Lazarini A" first="Argiro" last="Lazarini">Argiro Lazarini</name><name sortKey="Mavragani, Clio P" sort="Mavragani, Clio P" uniqKey="Mavragani C" first="Clio P." last="Mavragani">Clio P. Mavragani</name><name sortKey="Mavrommatis, Christos" sort="Mavrommatis, Christos" uniqKey="Mavrommatis C" first="Christos" last="Mavrommatis">Christos Mavrommatis</name><name sortKey="Melissaropoulos, Konstantinos" sort="Melissaropoulos, Konstantinos" uniqKey="Melissaropoulos K" first="Konstantinos" last="Melissaropoulos">Konstantinos Melissaropoulos</name><name sortKey="Ntelis, Konstantinos" sort="Ntelis, Konstantinos" uniqKey="Ntelis K" first="Konstantinos" last="Ntelis">Konstantinos Ntelis</name><name sortKey="Pantazi, Lina" sort="Pantazi, Lina" uniqKey="Pantazi L" first="Lina" last="Pantazi">Lina Pantazi</name><name sortKey="Papalopoulos, Ioannis" sort="Papalopoulos, Ioannis" uniqKey="Papalopoulos I" first="Ioannis" last="Papalopoulos">Ioannis Papalopoulos</name><name sortKey="Sakkas, Lazaros I" sort="Sakkas, Lazaros I" uniqKey="Sakkas L" first="Lazaros I." last="Sakkas">Lazaros I. Sakkas</name><name sortKey="Sfikakis, Petros P" sort="Sfikakis, Petros P" uniqKey="Sfikakis P" first="Petros P." last="Sfikakis">Petros P. Sfikakis</name><name sortKey="Sidiropoulos, Prodromos" sort="Sidiropoulos, Prodromos" uniqKey="Sidiropoulos P" first="Prodromos" last="Sidiropoulos">Prodromos Sidiropoulos</name><name sortKey="Tektonidou, Maria" sort="Tektonidou, Maria" uniqKey="Tektonidou M" first="Maria" last="Tektonidou">Maria Tektonidou</name><name sortKey="Tsatsani, Panagiota" sort="Tsatsani, Panagiota" uniqKey="Tsatsani P" first="Panagiota" last="Tsatsani">Panagiota Tsatsani</name><name sortKey="Vassilopoulos, Dimitrios" sort="Vassilopoulos, Dimitrios" uniqKey="Vassilopoulos D" first="Dimitrios" last="Vassilopoulos">Dimitrios Vassilopoulos</name><name sortKey="Vlachoyiannopoulos, Panagiotis G" sort="Vlachoyiannopoulos, Panagiotis G" uniqKey="Vlachoyiannopoulos P" first="Panagiotis G." last="Vlachoyiannopoulos">Panagiotis G. Vlachoyiannopoulos</name><name sortKey="Vounotrypidis, Periklis" sort="Vounotrypidis, Periklis" uniqKey="Vounotrypidis P" first="Periklis" last="Vounotrypidis">Periklis Vounotrypidis</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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